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GA regulated hepatic expression of FXR, PXR, and metabolic enzymes involved in BA detoxification in LCA-induced cholestatic liver injury. (A) Protein levels of FXR, PXR, and SHP were detected by Western blot analysis; (B) mRNA levels of Cyp3a11, Ugt1a1, Sult2a1, and Cyp7a1 were determined by RT-qPCR. Data are presented as mean ± SD (n = 5). #p < 0.05 and ##p < 0.01 vs. vehicle group; ∗ p < 0.05 and ∗∗∗ p < 0.001 vs. LCA group.
