We thank Makiyama and colleagues for their careful review and critique of our manuscript, Progression of Frailty in Survivors of Childhood Cancer: a St. Jude Lifetime Cohort Report, and for the suggestion that we construct an additional model to assure that frailty is in fact a cause of mortality in childhood cancer survivors (1). Given that we only had 77 deaths in the cohort, 22 related to a second malignant neoplasm and 20 to cardiac causes, our power to evaluate multiple risk factors for specific causes of death was limited. Our aim was to determine if frailty at one time point was associated with mortality over a 5- to 6-year time period, even after accounting for chronic disease. We continue to follow this cohort and will consider additional modeling of mortality outcomes in the future.
Funding
None.
Notes
Role of the funder: Not applicable.
Disclosures: The authors have no disclosures.
Author contributions: Writing, original draft—all authors; writing, editing and revision—all authors.
Data Availability
No new data were generated or used for this response.
Contributor Information
Angela Delaney, Department of Pediatric Medicine, St. Jude Children’s Research Hospital, Memphis, TN, USA.
Kirsten K Ness, Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, Memphis, TN, USA.
Reference
- 1. Makiyama J, Momosaki R, Yodoshi T, et al. RE: Progression of frailty in survivors of childhood cancer: a St. Jude Lifetime Cohort report. J Natl Cancer Inst. 2022;114(6):914–915. [DOI] [PMC free article] [PubMed] [Google Scholar]
Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Data Availability Statement
No new data were generated or used for this response.