Figure 2.

Association between early responses and overall survival in 16 first-line trials. From Sommeijer et al. (33), with permission. Best overall response, complete or partial response by RECIST within initial 26 weeks of treatment; C index (C) used for comparing the prediction accuracy of candidate surrogate endpoints, with values closer to 1 indicating better prediction accuracy; Confirmed response, complete or partial response by RECIST confirmed at least 4 weeks later during initial 26 weeks of treatment. The P values were calculated using 2-sided tests. The error bars represent the 95% confidence intervals (CIs) corresponding to the hazard ratios. ETS = early tumor shrinkage; EOTR = early objective tumor response; EnPD = no early progression; RECIST = Response Evaluation Criteria in Solid Tumours.