Figure 10.

The mannose receptor plays an important role in fungal survival inside Acanthamoeba castellanii and RAW macrophages. The phagocyte interaction assays with (A) Candida albicans, (B) Cryptococcus neoformans and (C) Histoplasma capsulatum were performed in the absence (solid circles) and presence of 100mM soluble mannose (empty circles), and fungal viability was assessed by determining the number of Colony Forming Units (CFUs) 24 h upon interaction to assess the fungicidal capacity of phagocytes (*p < 0.05, **p < 0.01 or ****p < 0.0001 indicate statistically significant decrease upon mannose inhibition; ns, not significant). The data represent the average of three independent experiments, performed in triplicates.