Figure 9.

Inhibition of mannose receptor impacts fungal survival inside Acanthamoeba castellanii and RAW macrophages. Fungal survival upon interactions with either (A–C) A. castellanii and (D–F) RAW 264.7 macrophages was evaluated for (A, D) Candida albicans, (B, E) Cryptococcus neoformans and (C, F) Histoplasma capsulatum were performed in the absence (Control group, black bars) and presence of 100 mM soluble mannose (Mannose 100 mM, white bars), and viability and mortality ratios were determined. The Mannose groups were compared to controls. Statistical differences are represented above each group (*p < 0.05, **p < 0.01, ***p < 0.001 or ****p < 0.0001 indicate statistically significant decrease upon mannose inhibition; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 or ^####p < 0.0001 indicate statistically significant increase upon mannose inhibition; ns, not significant). The bars represent the average of three independent experiments, performed in triplicates.