Table 1.
Demographic, cognitive and behavioural characterisation of patients and healthy controls.
| bvFTD (n = 17) | HC (n = 18) | p-value | |
|---|---|---|---|
| Women/Men | 5/12 | 10/8 | 0.12a |
| Age (years) | 64.4 (8.3) | 62.6 (7.2) | 0.42b |
| Disease duration (years) | 4.4 (2.3) | – | |
| Education (years) | 14.3 (4.9) | 13.8 (2.2) | 0.69.c |
| Cognitive tests (/max score) | |||
| MMSE (/30) | 23.7 (2.6) | 29.4 (0.8) | ***b |
| FAB (/18) | 12.5 (3.4) | 17.3 (0.8) | ***b |
| Mattis DRS (/144) | 119.2 (9.0) | 142.2 (1.3) | *** c |
| Picture naming task (/40) | 36.2 (3.6) | 39.4 (0.9) | *** b |
| Verbal semantic matching task (/40) | 36.5 (3.6) | 39.2 (1.1) | ** b |
| Direct verbal span | 5.3 (1.7) | – | |
| Indirect verbal span | 3.5 (1.2) | – | |
| Category fluency | 13.8 (7.3) | – | |
| Phonemic fluency | 8 (5.1) | – | |
| Hayling error score (/42) | 20.1 (15.1) | 3.1 (2.6) | ***b |
| Hayling time B-A | 119.4 (114.4) | 37 (17.9) | **c |
| Mini-SEA faux-pas (/15) | 8.3 (3.5) | 13.5 (1.1) | ***c |
| Mini-SEA recognition (/15) | 9.0 (2.5) | 13.0 (0.9) | ***c |
| Behavioural metrics | |||
| Compulsivity | 10.7 (17.3) | 0.2 (0.9) | ** b |
| Social disinhibition | 8.7 (6.9) | 3.3 (5.0) | ** b |
Data are given as mean (SD).
*P < 0.05; **P < 0.01; ***P < 0.001.
Abbreviations = bvFTD: behavioural variant frontotemporal dementia; FAB: frontal assessment battery; Hayling time B-A: time to complete part B of the test minus time to complete part A of the test. Hayling error score: total error score on the Hayling Test; Mattis DRS: Mattis Dementia Rating Scale; Mini-SEA: mini- social & emotional assessment; MMSE: mini-mental state examination; n.s. = non-significant.
a
Chi-square test.
b
Wilcoxon test.
c
Aspin Welch test.