Table 1. Characteristics of Children With a Community-Onset Severe Bacterial Infection and Their Association With Outcome on Bivariable Analysis.
| Characteristic | Patients, No. (%) | Bivariable analyses | ||||||
|---|---|---|---|---|---|---|---|---|
| Total (N = 259) | Surviving without sequelae (n = 207) | Died (n = 27) | Surviving with sequelae (n = 25) | Surviving without sequelae vs died | Surviving without sequelae vs surviving with sequelae | |||
| OR (95% CI) | P value | OR (95% CI) | P value | |||||
| Age | ||||||||
| Median (IQR), mo | 24 (6-66) | 28 (7-72) | 19 (5-35) | 13 (5-27) | NA | NA | NA | NA |
| 1 mo to 5 y | 185 (71.4) | 141 (68.1) | 23 (85.2) | 21 (84.0) | 2.69 (0.89-8.10) | .08 | 2.46 (0.81-7.44) | .11 |
| ≥5 y | 74 (28.6) | 66 (31.9) | 4 (14.8) | 4 (16.0) | 1 [Reference] | 1 [Reference] | ||
| Sex | ||||||||
| Female | 116 (44.8) | 92 (44.4) | 15 (55.6) | 9 (36.0) | 1.56 (0.70-3.50) | .28 | 0.70 (0.30-1.66) | .42 |
| Male | 143 (55.2) | 115 (55.6) | 12 (44.4) | 16 (64.0) | 1 [Reference] | 1 [Reference] | ||
| Comorbidities | ||||||||
| Yes | 63 (24.3) | 45 (21.7) | 12 (44.4) | 6 (24.0) | 2.88 (1.26-6.59) | .01 | 1.14 (0.43-3.01) | .80 |
| No | 196 (75.7) | 162 (78.3) | 15 (55.6) | 19 (76.0) | 1 [Reference] | 1 [Reference] | ||
| Hemodynamic severity signs at first consultation | ||||||||
| Yes | 71 (27.4) | 51 (24.6) | 14 (51.9) | 6 (24.0) | 3.29 (1.45-7.47) | .004 | 0.97 (0.37-2.55) | .94 |
| No | 188 (72.6) | 156 (75.4) | 13 (48.1) | 19 (76.0) | 1 [Reference] | 1 [Reference] | ||
| Discharge diagnosis | ||||||||
| Meningitis | 84 (32.4) | 66 (31.9) | 8 (29.6) | 10 (40.0) | 1.94 (0.56-6.76) | .30 | 1.94 (0.63-5.99) | .25 |
| Purpura fulminans | 59 (22.8) | 44 (21.3) | 9 (33.4) | 6 (24.0) | 3.27 (0.95-11.30) | .06 | 1.75 (0.50-6.08) | .38 |
| Sepsis with no source | 43 (16.6) | 33 (15.9) | 6 (22.2) | 4 (16.0) | 2.91 (0.77-11.03) | .12 | 1.55 (0.39-6.17) | .53 |
| Othera | 73 (28.2) | 64 (30.9) | 4 (14.8) | 5 (20.0) | 1 [Reference] | NA | 1 [Reference] | NA |
Abbreviations: NA, not applicable; OR, odds ratio.
a
Other diagnosis includes pulmonary, urinary, osteoarticular, intra-abdominal, cardiac, and soft-tissue severe infections.