Figure 2.

Male heterozygous Kdm6b knockout mice display impaired object recognition memory. (A) Diagram showing the experimental procedure for the novel object recognition test. (B) Representative heatmap showing the time that male wild-type and heterozygote Kdm6b-KO mice spent exploring the familiar and novel object. (C) Quantitative results showing the NOR discrimination ratio of male mice. n = 8 per genotype. P-values calculated using a two-tailed t-test. **P < 0.01. Error bars in graphs represent mean ± SEM. (D) Quantitative results showing the NOR discrimination ratio of female mice. n = 7 per genotype. P-values calculated using a two-tailed t-test. ns: not significant. Error bars in graphs represent mean ± SEM.