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. 2022 May 31;10:920162. doi: 10.3389/fbioe.2022.920162

FIGURE 2.

FIGURE 2

Multifunctional Apt-DNA-Au nanomachines for in situ imaging and targeted multimodal synergistic cancer therapy. (A) Schematic diagram of the structure of the Apt-DNA-Au nanomachine. MUC1 segment is an aptamer that specifically recognizes MCF-7 cells; A segment and Fd segment contain G-quadruplex structure for loading photosensitizer (ZnPc); C segment is labeled with Cy5 for in situ fluorescence imaging; D segment is incorporated into antisense DNA that inhibits Survivin expression for inhibiting tumor cell proliferation; TD segment is an A/C/D mixture loaded with Dox. (B) Working principle of the Apt-DNA-Au nanomachine. (C) Apt-DNA-Au nanomachines specifically recognize and internalize to target cancer cells, and monitor tumor therapeutic effects in real time through in situ fluorescence imaging and multimodal anticancer therapy (combined with chemotherapy, gene therapy, PDT, and PTT). Reproduced with permission from (Yu et al., 2021).