FIGURE 4.

Schematic diagram of the synthesis and working principle of Cu-LDH/HMME@Lips. (A) Schematic diagram of the synthesis of Cu-LDH/HMME@Lips. (B) Schematic diagram of the working principle of Cu-LDH/HMME@Lips. Dual-size/charge-switchable Cu-LDH/HMME@Lips utilizes negatively charged liposomes to prolong circulation residence time in low-permeability solid tumor models, and then HMME decompose Cu-LDH/HMME@Lips in response to ultrasound to release positively charged Cu-LDH, which can penetrate deep into tumor cells. HMM generates ¹O₂ under ultrasound irradiation, while Cu-LDH infiltrates deep in tumor generates ROS through a Fenton-like reaction. Reproduced with permission from (Wu et al., 2021).