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. 2022 May 31;10:920162. doi: 10.3389/fbioe.2022.920162

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Copyright © 2022 Chen, Huang, Li, Huang, Zeng, Zheng, Peng and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure of prostacyclin and its sensitizing effect in tumor cells. After PGIL is taken up by cancer cells, ¹O₂ generated by Ce6 triggered by NIR causes the liposomes in the outer layer to rupture, releasing Ce6 and LCP. Ce6 mediates PDT, while LCP enhances PDT-induced apoptosis, inhibits cell metastasis, and activates NK cell-mediated immune clearance by inhibiting galectin-3. Abbreviations: Gal-3, galectin-3 protein. Reproduced with permission from (Wang et al., 2019).