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. 2022 May 31;13:881708. doi: 10.3389/fphar.2022.881708

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Copyright © 2022 Hannawi, Ewees, Moore and Zweier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IHC staining for eNOS, nNOS, and iNOS in the brains of WKY and SHRSP. Significant differences consistent with lower eNOS and nNOS expression were detected in SHRSP in comparison to age matched WKY (A–D). iNOS showed higher expression in SHRSP in comparison to WKY at the same time points (E,F). eNOS was also significantly lower in 24-week WKY in comparison to 7-week WKY. There were no additional differences according to age in nNOS and iNOS expression. eNOS: endothelial nitric oxide synthase; iNOS: inducible nitric oxide synthase; nNOS: neuronal nitric oxide synthase; SHRSP: spontaneously hypertensive stroke-prone rats; WKY: Wistar Kyoto rats; ns: not statistically significant; *: p < 0.05; **: p < 0.01. Data represent the means and standard errors.