Table 1.
Demographic and clinicopathological characteristics in pancreatic cancer patients.
| Characteristic |
Training cohort (n
=
13,348) No. of patients % |
Validation cohort (n
=
5,719) No. of patients % |
P-value | ||
|---|---|---|---|---|---|
| Age | 0.417# | ||||
| Median | 67 | 67 | |||
| Range | 59–75 | 59–74 | |||
| Race | 0.552 | ||||
| White | 10,720 | 80.3 | 4,556 | 79.7 | |
| Black | 1,470 | 11.0 | 658 | 11.5 | |
| Other | 1,158 | 8.7 | 505 | 8.8 | |
| Sex | 0.966 | ||||
| Female | 6,428 | 48.2 | 2,756 | 48.2 | |
| Male | 6,920 | 51.8 | 2,963 | 51.8 | |
| Histological subtype | 0.298 | ||||
| Adenocarcinoma | 6,854 | 51.3 | 2,966 | 51.9 | |
| Infiltrating duct carcinoma | 3,554 | 26.6 | 1,557 | 27.2 | |
| Neuroendocrine carcinoma | 1,008 | 7.6 | 426 | 7.4 | |
| Other | 1,932 | 14.5 | 770 | 13.5 | |
| Grade | 0.703 | ||||
| Well-differentiated: I | 2,849 | 21.3 | 1,210 | 21.2 | |
| Moderately differentiated: II | 5,509 | 41.3 | 2,335 | 40.8 | |
| Poorly differentiated: III | 4,708 | 35.3 | 2,040 | 35.7 | |
| Undifferentiated; anaplastic: IV | 282 | 2.1 | 134 | 2.3 | |
| Primary site | 0.309 | ||||
| Head of pancreas | 7,766 | 58.2 | 3,399 | 59.4 | |
| Body of pancreas | 1,625 | 12.2 | 680 | 11.9 | |
| Tail of pancreas | 2,234 | 16.7 | 919 | 16.1 | |
| Pancreatic duct | 65 | 0.5 | 19 | 0.3 | |
| Other specified parts of pancreas | 227 | 1.7 | 80 | 1.4 | |
| Overlapping lesion of pancreas | 868 | 6.5 | 371 | 6.5 | |
| Pancreas, NOS | 563 | 4.2 | 251 | 4.4 | |
| AJCC T stage | 0.520 | ||||
| T1 | 1,264 | 9.5 | 508 | 8.9 | |
| T2 | 2,592 | 19.4 | 1,136 | 19.9 | |
| T3 | 7,719 | 57.8 | 3,296 | 57.6 | |
| T4 | 1,773 | 13.3 | 779 | 13.6 | |
| AJCC N stage | 0.900 | ||||
| N0 | 6,476 | 48.5 | 2,769 | 48.4 | |
| N1 | 6,872 | 51.5 | 2,950 | 51.6 | |
| Surgery | 0.552 | ||||
| No | 4,749 | 35.6 | 2,009 | 35.1 | |
| Yes | 8,599 | 64.6 | 3,710 | 64.9 | |
| Radiotherapy | 0.564 | ||||
| No | 10,462 | 78.4 | 4,461 | 78.0 | |
| Yes | 2,886 | 21.6 | 1,258 | 22.0 | |
| Chemotherapy | 0.256 | ||||
| No | 5,685 | 42.6 | 2,385 | 41.7 | |
| Yes | 7,663 | 57.4 | 3,334 | 58.3 | |
| Tumor size | 0.462# | ||||
| Median | 35 | 35 | |||
| Range | 25–46 | 25–46 | |||
| Brain metastasis | 0.536 | ||||
| No | 13,332 | 99.9 | 5,714 | 99.9 | |
| Yes | 16 | 0.1 | 5 | 0.1 | |
| Bone metastasis | 0.831 | ||||
| No | 13,182 | 98.8 | 5,650 | 98.8 | |
| Yes | 166 | 0.2 | 69 | 0.2 | |
| Liver metastasis | 0.704 | ||||
| No | 11,082 | 83.0 | 4,761 | 83.2 | |
| Yes | 2,266 | 17.0 | 958 | 16.8 | |
| Lung metastasis | 0.841 | ||||
| No | 12,787 | 95.8 | 5,475 | 95.7 | |
| Yes | 561 | 4.2 | 244 | 4.3 | |
# Mann-Whitney U-test.