Table 2.
Demographic and clinicopathological characteristics of pancreatic cancer patients with lung metastases in training cohort.
| Characteristic |
Without LM cohort (n
=
12,787) No. of patients % |
With LM cohort (n
=
561) No. of patients % |
P-value | ||
|---|---|---|---|---|---|
| Age | 0.013# | ||||
| Median | 67 | 68 | |||
| Range | 59–75 | 60–76.5 | |||
| Race | 0.125 | ||||
| White | 10,286 | 80.4 | 434 | 77.4 | |
| Black | 1,394 | 10.9 | 76 | 13.5 | |
| Other | 1,107 | 8.7 | 51 | 9.1 | |
| Sex | 0.087 | ||||
| Female | 6,138 | 48.0 | 290 | 51.7 | |
| Male | 6,649 | 52.0 | 271 | 48.3 | |
| Histological subtype | <0.001 | ||||
| Adenocarcinoma | 6,456 | 50.5 | 398 | 70.9 | |
| Infiltrating duct carcinoma | 3,484 | 27.2 | 70 | 12.5 | |
| Neuroendocrine carcinoma | 981 | 7.7 | 27 | 4.8 | |
| Other | 1,866 | 14.6 | 66 | 11.8 | |
| Grade | <0.001 | ||||
| Well-differentiated: I | 2,794 | 21.9 | 55 | 9.8 | |
| Moderately differentiated: II | 5,299 | 41.4 | 210 | 37.4 | |
| Poorly differentiated: III | 4,438 | 34.7 | 270 | 48.1 | |
| Undifferentiated; anaplastic: IV | 256 | 2.0 | 26 | 4.6 | |
| Primary site | <0.001 | ||||
| Head of pancreas | 7,551 | 59.1 | 215 | 38.3 | |
| Body of pancreas | 1,518 | 11.9 | 107 | 19.1 | |
| Tail of pancreas | 2,098 | 16.4 | 136 | 24.2 | |
| Pancreatic duct | 61 | 0.5 | 4 | 0.7 | |
| Other specified parts of pancreas | 218 | 1.7 | 9 | 1.6 | |
| Overlapping lesion of pancreas | 814 | 6.4 | 54 | 9.6 | |
| Pancreas, NOS | 527 | 4.1 | 36 | 6.4 | |
| AJCC T stage | <0.001 | ||||
| T1 | 1,246 | 9.7 | 18 | 3.2 | |
| T2 | 2,418 | 18.9 | 174 | 31.0 | |
| T3 | 7,511 | 58.7 | 208 | 37.1 | |
| T4 | 1,612 | 12.6 | 161 | 28.7 | |
| AJCC N stage | 0.007 | ||||
| N0 | 6,235 | 48.8 | 241 | 43.0 | |
| N1 | 6,552 | 51.2 | 320 | 57.0 | |
| Surgery | <0.001 | ||||
| No | 4,232 | 33.1 | 517 | 92.2 | |
| Yes | 8,555 | 66.9 | 44 | 7.8 | |
| Radiotherapy | <0.001 | ||||
| No | 9,952 | 77.8 | 510 | 90.9 | |
| Yes | 2,835 | 22.2 | 51 | 9.1 | |
| Chemotherapy | 0.340 | ||||
| No | 5,457 | 42.7 | 228 | 40.6 | |
| Yes | 7,330 | 57.3 | 333 | 59.4 | |
| Tumor size | <0.001# | ||||
| Median | 35 | 45 | |||
| Range | 25–45 | 33–60 | |||
| Brain metastasis | <0.001 | ||||
| No | 12,779 | 99.9 | 553 | 98.6 | |
| Yes | 8 | 0.1 | 8 | 1.4 | |
| Bone metastasis | <0.001 | ||||
| No | 12,678 | 99.1 | 504 | 89.8 | |
| Yes | 109 | 0.9 | 57 | 10.2 | |
| Liver metastasis | <0.001 | ||||
| No | 10,831 | 84.7 | 251 | 44.7 | |
| Yes | 1,956 | 15.3 | 310 | 55.3 | |
# Mann-Whitney U-test.