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. 2022 May 4;298(6):102009. doi: 10.1016/j.jbc.2022.102009

Figure 5.

Figure 5

Mutations of the predicted 3hi2one-G4 binding site on GIRK4 channel expressed in Xenopus oocytes.A, GIRK4 basal (HK, gray bars) and 3hi2one-G4 activator–induced current (green bars). B, normalized 3hi2one-G4 activator–induced current (I/Ibasal). The asterisks indicate significant differences of GIRK4 channel mutants by one-way ANOVA Tukey’s tests (∗∗∗p < 0.001) compared with GIRK4 wildtype channel (data are mean ± SD, N ≥ 4). GIRK, G protein–sensitive inwardly rectifying potassium channel; 3hi3one, 3-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1-(1-naphthylmethyl)-1,3-dihydro-2H-indol-3-one; HK, high potassium.