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. 2022 May 17;298(6):102037. doi: 10.1016/j.jbc.2022.102037

Table 1.

NAD+-consuming enzymes in the maintenance of genome integrity—major members and targets

Class of enzymes Specific NAD+ consuming members followed by target proteins
ARTDs

  • PARP1: ATM (226), BRCA1 (72), CHD (227), DDB1–DDB2 (228), DNA-PKcs (73), FUS (229), LIG III (230), MRN (74), NELF (79), RECQ1 (75), SAFB1 (231), SMARCA5 (76), TDP1 (232), Timeless (233), XPA (234), and XRCC1 (71)

  • PARP2: HP1 (235), PARP1, and XRCC1 (236)

  • PARP3: APLF (237), DNA-PKcs, LIG IV, Ku70, Ku80, XRCC4 (238), NuMA, and TNKS1 (239)

  • PARP9: BBAP (240)

  • PARP10: PCNA and RAD51 (241)

  • PARP14: PCNA (242)

  • TNKS1: MDC1 (243) and MERIT40 (244)

  • TNKS2: MDC1 (243)
SIRTs

  • SIRT1: APE1 (245), Ku70 (246), NBS1 (247), TDG (248), WRN (249), and XPA (250)

  • SIRT2: ATRIP (145), CDK9 (251), and H3 (142)

  • SIRT3: Ku70 (146), OGG1 (148), and RAD52 (147)

  • SIRT6: DNA-PKcs (McCord et al., 2009), H3 (123), Ku80 (Chen et al., 2017), and PARP1 (133, 166)

  • SIRT7: ATM (136), CDK9 (139), H3 (124, 134)
NAD+-dependent LIG LIG IV (60)