Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 18;154(6):e202112981. doi: 10.1085/jgp.202112981

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Marquis and Sack

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure S3. — Conservation of pore-lining residues of Kv2 orthologs and paralogs. The Rattus norvegicus Kv2.1 (RnKv2.1) sequence is used for residue numbering at top. Homology to Kv1.2 was used to infer the locations of pore-lining residues (purple highlights) in RnKv2.1. (A) Conservation of pore-lining residues of RnKv2.1 with Kv2-family orthologs. Alignments created in Jalview 2.11.1.4 (Waterhouse et al., 2009). Dots represent residues in protein subunits that are identical to corresponding residues in RnKv2.1. Residues forming the tetraalkylammonium binding site in RnKv1.2 (Lenaeus et al., 2014; Long et al., 2005) are shown in black. Species: Homo sapiens (Hs), Gallus gallus (Gg), Ophiophagus Hannah (Oh), Xenopus laevis (Xl), Danio rerio (Dr), Mytilus coruscus (Mc), Drosophila melanogaster (Dm), Caenorhabditis elegans (Ce), Nematostella vectensis (Nv). (B) Conservation of pore-lining residues of mammalian Kv2.1 with KvS silent subunits.