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. 2022 Apr 18;154(6):e202112981. doi: 10.1085/jgp.202112981

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© 2022 Marquis and Sack

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Scheme 1. — Proposed mechanism of inhibition. State diagram depicting a Kv2.1 channel gating in the presence of RY785 (red rectangle). RY785 has access only to voltage-activated conformations of the channel. RY785 promotes deactivation and is trapped by deactivation of voltage sensors to a resting state.