Table 1.
Potential targets of the miR-216/217 cluster.
| miRNA | Target score | Gene | Function |
|---|---|---|---|
| gga-miR-216a | 94 | TOB1 | Negative regulation of cell proliferation; tumor suppressor |
| 93 | SYNJ1 | Phosphatidylinositol phosphate metabolism | |
| 93 | HACD2/(PTPLB) | Sphingolipid biosynthetic process; very long-chain FA biosynthetic process | |
| 91 | NAA15 | N-terminal protein amino acid acetylation; angiogenesis;cell differentiation | |
| 91 | NADKD1 | NADP biosynthetic process; phosphorylation | |
| 89 | LNPEP | Insulin-mediated glucose transport | |
| gga-miR-216b | 97 | FBXO8 | Correlate with poor survival in hepatocellular carcinoma |
| 92 | ETNK1 | Plasmalogen biosynthesis | |
| 86 | SERBP1 | Apoptosis-related network due to altered Notch3 in ovarian cancer | |
| 84 | ZNF423 | TGF-β receptor signaling | |
| gga-miR-217-5p | 100 | RIMS2 | Cell differentiation; insulin secretion; Rab GTPase binding |
| 100 | MIER3 | Suppress cancer progression; tumor suppressor | |
| 100 | YAF2 | Negative regulation of G0 to G1 transition; cell cycle | |
| 99 | FBN2 | Sequestering of TGF-β in extracellular matrix | |
| 99 | TM9SF3 | Participate in tumor invasion | |
| 98 | PPM1D | G2/M transition of mitotic cell cycle |