Table 1.

Association of glycosyltransferase expression levels with the survival of patients with chronic lymphocytic leukemia.

Parameter	Hazard ratio (95% CI) by univariate analysis	Hazard ratio (95% CI) by multivariate analysis with age and IGHV mutation as covariates
Age (per year)	1.04 (1.01–1.07; P = 0.008)	1.04 (1.01–1.07; P = 0.015)
IGHV mutation (mutated/unmutated)	0.12 (0.06–0.24; P < 0.001)	0.15 (0.07–0.32; P < 0.001)
GCNT1 (G) and ST6GALNAC4 (S)
G high S high/G high S low	3.25 (1.07–9.91; P = 0.038)	1.87 (0.59–5.96; P = 0.289)
G low S high/G high S low	7.61 (2.60–22.27; P < 0.001)	3.59 (1.16–11.12; P = 0.026)
G low S low/G high S low	4.62 (1.03–20.88; P = 0.045)	1.38 (0.27–7.00; P = 0.701)

Analyses of the association of GCNT1 and ST6GALNAC4 with mortality, with or without clinical covariates, were performed using International Cancer Genome Consortium data (n = 264) as described in Methods. The cutoff value for sample subgrouping was based on the optimal cutoff for gene expression (3.3 and 10.3 for GCNT1 and ST6GALNAC4, respectively) fitted in the Cox proportional hazards model. P values are based on likelihood ratio test. CI, confidence interval.