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. 2022 May 30;13:895698. doi: 10.3389/fpls.2022.895698

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Copyright © 2022 Lim, Lim and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Degradation of ABA core components by the 26S ubiquitin-proteasome system and endosomal-vacuole pathway. PYR1/PYLs are degraded by RSL1, RFA1/RFA4, and CRL4^DDA1 through ubiquitin-proteasome system. RSL1 ubiquitinates PYR1/PYL4 on the plasma membrane (PM), after that ubiquitinated substrates are degraded by ESCRT components, FIVE1/VPS23A/ALIX via endosomal-vacuole pathway. RFA1- and RFA4/CRL4^DDA1-mediated ubiquitination processes occur in the cytosol and nucleus, respectively. PP2Cs are degraded by PUB12/13, CRL3^{BPM3/5(BTB-MATH)}, PIR1/2, and RGLG1/5 through 26S proteasome. PUB12/13 degrade ABI1 by ubiquitination in the PM. RGLG1/5 ubiquitinate PP2CA/ABI2/HAB2, CRL3^{BPM3/5(BTB-MATH)} ubiquitinate PP2CA/ABI1/HAB1, and PIR1/2 ubiquitinates PP2CA in the nucleus. This figure has been modified from Coego et al. (2021).