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. 2022 Jun 14;20:278. doi: 10.1186/s12951-022-01490-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Improvement of locomotor recovery and neurons survival by TSIIA@SeNPs-APS in SCI rats. A BBB scores and B Inclined plane test of rats at different times. Significant difference between TSIIA@SeNPs-APS group and SCI group is indicated by *P < 0.05, **P < 0.01 and ***P < 0.001. C Footprint analysis of rats in each group. D Snapshots extracted from video recordings showing a sequence of hindlimb movements rats in each group while walking. Iliac crest, knee, and ankle joints were showed by dots and lines. The moving direction of hindlimb was showed by arrow. Representative images of E H&E staining, F Nissl staining, and G TUNEL/DAPI double-staining of spinal cord tissues in each group. Black arrows: motor neurons in E and Nissl bodies in F