Table 2.

Concentrations of (N-desethyl-)sunitinib in plasma and serum correlate with changes in platelet count and aggregation in RCC patients at different time points

Variables		Time point	Change in platelet count				Correlation
			-∆Plt median (IQR)	n	+∆Plt median (IQR)	n	R	P-value
Sunitinib	Plasma	Week 2	78.5 (60.5-108.3)	n = 14	61.4 (55.3-81.8)	n = 3	−0.4966	0.0443*
	Serum		80.6 (57.4-104.3)	n = 14	64.0 (55.4-69.4)	n = 3	−0.5221	0.0336*
	Pellet		0.29 (0.18-0.54)	n = 12	0.20 (0.00-0.28)	n = 3	−0.4480	0.0960
	Plasma	Week 4	56.0 (43.0-73.5)	n = 14	–	n = 0	−0.4066	0.1505
	Serum		59.3 (40.3-81.0)	n = 14	–	n = 0	−0.3846	0.1755
	Pellet		0.18 (0.09-0.28)	n = 13	–	n = 0	−0.2707	0.3701
N-desethyl-Sunitinib	Plasma	Week 2	26.0 (21.0-35.3)	n = 14	21.6 (14.8-23.2)	n = 3	−0.7353	0.0011**
	Serum		26.2 (18.6-34.3)	n = 14	18.6 (16.1-20.3)	n = 3	−0.6152	0.0100*
	Pellet		0.43 (0.35-0.67)	n = 12	0.27 (0.00-0.56)	n = 3	−0.5147	0.0517
	Plasma	Week 4	24.0 (17.0-31.5)	n = 14	–	n = 0	−0.7099	0.0058**
	Serum		22.3 (17.5-30.7)	n = 14	–	n = 0	−0.7143	0.0054**
	Pellet		0.39 (0.15-0.73)	n = 13	–	n = 0	−0.5557	0.0515
∆Aggregation		Week 2	−9.8 (−24.3 - -1.9)	n = 11	−5.7 (−6.6 - 35.6)	n = 3	0.6249	0.0192*
		Week 4	−7.1 (−44.7 - 4.4)	n = 13	–	n = 0	0.1099	0.7231
		Month 3	−6.6 (−17.3 - 0.3)	n = 10	−17.6 (− 18.1 - -17.1)	n = 2	−0.5515	0.1049

IQR Interquartile range, ΔPlt count Platelet count at indicated timepoint on treatment – platelet count before treatment, Negative value (−ΔPlt) indicates a reduction in platelet count; Positive value (+ΔPlt) indicates an increase in platelet count. Correlations are based on all changes in platelet count