Fig. 2.
The fecal microbiota from double Dectin-deficient mice ameliorates DSS-induced colitis. A Wild-type (WT) and Dectin-1/2-deficient (D-1/2KO) mice received dextran sulfate sodium (DSS) for 7 days. WT n = 13, D-1/2KO n = 15. A Bacterial (left panel) and fungal (right panel) quantities in feces at day 0, day 7, and day 12, determined by qPCR. B–G Wild-type mice from Janvier Laboratory transplanted with their own intestinal microbiota (WTjWTj) or transplanted with the intestinal microbiota of Dectin-1/2-deficient mice (WTjD-1/2KO) received DSS for 7 days. WTjWTj n = 18, WTjD-1/2KO n = 20. H–M Dectin-1/2-deficient mice transplanted with their own intestinal microbiota (D-1/2KOD-1/2KO) or transplanted with the intestinal microbiota of wild-type mice from Janvier Laboratory (D-1/2KOWTj) received DSS for 7 days. D-1/2KOD-1/2KO n = 17, D-1/2KOWTj n = 18. B/H Experimental design for fecal microbiota transplantation and administration of DSS. C/I Weight of DSS-exposed mice. D/J Disease activity index (DAI) of DSS-exposed mice. E/K Length of the colons of mice treated with DSS. F/L Histological scores on day 12. G/M Intestinal inflammation, expressed as the lipocalin levels in feces at day 0, day 7, and day 12. *p < 0.05, **p < 0.01, ***p < 0.001