Fig. 5.

Lachnospiraceae strains can protect mice from DSS-induced colitis. A ELISA of the expression of IL-6 in BMDC cultures from wild-type (WT) and Dectin-1/2-deficient (D-1/2KO) mice stimulated with dead bacteria. B–E Mice received several Lachnospiraceae (BM38, BM62, or Blautia) or medium (vehicle) and dextran sulfate sodium (DSS) for 7 days. Vehicle n = 17, BM38 n = 18, BM62 n = 10, Blautia n = 10. B Experimental design for the administration of Lachnospiraceae and DSS. C Weight of DSS-exposed mice. D Disease activity index (DAI) of DSS-exposed mice. E Length of the colons of mice treated with DSS. For statistical comparisons, (*) indicates Blautia versus vehicle, and ($) indicates BM38 versus vehicle. *^,$p < 0.05, **p < 0.01, ***p < 0.001