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The concentration versus time profile in whole blood of Cu and Mn during (red-highlighted area) and after exposure. Statistical analysis of Mn was performed using one-way ANOVA with Dunnett’s post hoc test, while that of Cu was performed by Kruskal–Wallis test (compare to the control group). Data are expressed as mean ± SD (n = 5). ****P < 0.0001, *** P < 0.001, **P < 0.01, *P < 0.05
