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. 2022 Jun 13;22:158. doi: 10.1186/s12906-022-03629-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Effect of ECN treatment on survival rate, distress symptoms, and arthritic index. A Survival rate showed no significant difference amongst the studied groups. B The ECN showed significant improvement in the distress symptoms (Dull/Ruffled coat, change in temperament, reluctance to move) compared to the CFA treated group. C Furthermore, the ECN treatment markedly improved the arthritic score in contrast to CFA treated group. The data were represented as the mean ± SD (n = 7). (*) p < 0.05, (**) p < 0.01 and (***) p < 0.001 indicates significant differences from the CFA control group, while (###) means comparison with the CFA treated group