Table 3.
Previously identified potential salivary miRNA biomarkers associated with persistent post–concussive symptoms (PPCS).
| Association in other studies | Associated with PPCS in our cohort? | P–value in current study | |
|---|---|---|---|
| Previously identified salivary miRNA that are expressed in current study | |||
| hsa–miR−203a−5p | PPCS (19) | Yes | 0.00319 |
| hsa–miR−148–3p | PPCS (19) | No | hsa–miR−148a−3p: 0.28106 hsa–miR−148b−3p: 0.52139 |
| hsa–miR−1246 | PPCS (19) | No | 0.85564 |
| Previously identified salivary miRNA that are not expressed or not measured in current study | |||
| hsa–miR−320c−1 | PPCS (18) | No | NA |
| hsa–miR−133a−5p | PPCS (18) | No | NA |
| hsa–miR−769–5p | PPCS (18) | No | NA |
| hsa–let−7a−3p | PPCS (18) | Not measured | NA |
| hsa–miR−100–5p | PPCS (19) | No | NA |
| hsa–miR−148a−5p | PPCS (19) | Not measured | NA |
| hsa–miR−423–5p | PPCS (19) | No | NA |
| hsa–miR−92b−3p | PPCS (19) | No | NA |
| hsa–miR−1307–3p | PPCS (18) | No | NA |
| Salivary miRNA significantly expressed in current study that were not previously identified | |||
| hsa–miR−548y | NA | Yes | 0.00015 |
| hsa–miR−585–3p | NA | Yes | 0.00015 |
| hsa–miR−378h | NA | Yes | 0.00015 |
| hsa–miR−1323 | NA | Yes | 0.00015 |
| hsa–miR−183–5p | NA | Yes | 0.00015 |
| hsa–miR−199a−3p+hsa–miR−199b−3p | NA | Yes | 0.00015 |
| hsa–miR−301a−5p | NA | Yes | 0.00148 |
| hsa–miR−626 | NA | Yes | 0.00244 |
| hsa–miR−888–5p | NA | Yes | 0.00518 |
| hsa–miR−548e−5p | NA | Yes | 0.00696 |
| hsa–miR−200a−3p | NA | Yes | 0.00789 |
| hsa–miR−95–3p | NA | Yes | 0.01010 |