Figure 2.

AMK+BIO-PLY treatment decreased bacterial load in the synovial fluid and synovial tissue and reduced clinical signs of infection. (A) Synovial fluid biofilm aggregates were observed macroscopically in all horses prior to treatment on day 1. (B) Synovial fluid bacterial load was reported as log colony forming units (CFU) per milliliter (mL). (C) Bacterial load in the synovial tissue reported as CFU per gram (g). (D) Representative photographs of control and treatment limbs evaluated for joint effusion (arrowheads) and limb edema (arrows). Unaffected contralateral limbs are included for each horse as a normal comparison. (E) Total pain scores as evaluated for clinical signs of infection for control and treatment limbs where 0 = most normal. Means and standard deviations of each group (control vs treatment; n=6), and significant differences *p<0.05, **p<0.01, ***p<0.001 were determined by the Wilcoxon rank-sum test comparing control and treatment at each day.