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. 2022 May 30;16:893190. doi: 10.3389/fncel.2022.893190

FIGURE 1.

FIGURE 1

Knockout of dopamine D3 receptor gene attenuated METH-induced long-term behavioral sensitization. (A) Administration schedules. Days 1–2: mice were injected i.p. in volumes of 10 ml/kg once daily with saline and their horizontal locomotor activities were measured for 60 min after the injections to habituate to the open field and drug treatment. Days 3–7, days 10–14, days 17–21, days 24–28, and day 85: for the 2 mg/kg METH and saline groups, mice were given once-daily injections of either METH or saline, respectively, and their horizontal locomotor activities were determined for 60 min after the injections. Days 8–9, days 15–16, days 22–23, and days 29–84: mice were left undisturbed. (B–F) The locomotor activities of mice after i.p. injection of 2 mg/kg METH or saline on days 1–10 (B), days 11–14 (C), days 17–21 (D), days 24–28 (E), and day 85 (F). Values are presented as mean ±SEM. *P < 0.05 compared with the same genotype in saline group; #P < 0.05 compared with same-dose WT mice; +P < 0.05 compared with day 3. WT, wild type.