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. 2022 May 30;16:893190. doi: 10.3389/fncel.2022.893190

FIGURE 2.

FIGURE 2

Knockout of dopamine D3 receptor gene blocked the changes of dopamine D1 receptor-positive synapses in the NAcsh of METH-sensitized mice. (A) Nucleus accumbens (NAc) diagram of mice. Coronal brain section representing relative sites of NAcsh (Paxinos et al., 2001) (Gray-shaded area). (B–E) Ultrastructure photos showed synapses in the NAcsh of mice. The red arrows indicated the dopamine D1 receptor-positive synapses, the yellow arrows indicated the silver-intensified gold particles, and the blue arrows indicated the non-positive synapses. Scale bars = 500 μm. (F–G) Quantification of the number (F) and rate (G) of the dopamine D1 receptor-positive synapses of the four groups of mice (n = 3 mice each). *P < 0.05 compared with the same genotype in saline group; #P < 0.05 compared with same-dose WT mice. Values are presented as mean ±SEM. NAcc, nucleus accumben core; NAcsh, nucleus accumben shell; aca, anterior commissure; CPu, caudate putamen; WT, wild type.