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. 2022 May 30;16:893190. doi: 10.3389/fncel.2022.893190

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Copyright © 2022 Wang, Li, Su, Wang, Ma, Wang, Zhu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockout of dopamine D3 receptor gene blocked the changes of D1R-positive cells in the NAcsh of METH-sensitized mice. (A) Fluorescent staining of the dopamine D1 receptor in the NAcsh. The red arrows indicated the D1R-positive cells. Scale bars = 50 μm. (B,C) Quantification of the number (B) and rate (C) of D1R-positive cells in the NAcsh of the four groups of mice (n = 3 mice each). *P < 0.05 compared with the same genotype in saline group; ^#P < 0.05 compared with same-dose WT mice; ^&P < 0.05 compared with the different genotype in saline group. Values are presented as mean ±SEM. WT, wild type.