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. 2022 May 30;16:893190. doi: 10.3389/fncel.2022.893190

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Copyright © 2022 Wang, Li, Su, Wang, Ma, Wang, Zhu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockout of dopamine D3 receptor gene blocked the changes of glutamate NR2B-positive synapses in the NAcsh of METH-sensitized mice. (A–D) Ultrastructure photos showed synapses in the NAcsh of mice. The red arrows indicated the glutamate NR2B-positive synapses, the yellow arrows indicated the silver-intensified gold particles, and the blue arrows indicated the non-positive synapses. Scale bars = 500 nm. (E,F) Quantification of the number (E) and rate (F) of the glutamate NR2B-positive synapses of the four groups of mice (n = 3 mice each). *P < 0.05 compared with the same genotype in saline group; ^#P < 0.05 compared with same-dose WT mice. Values are presented as mean ±SEM. WT, wild type.