Table 2.

Second-order rate constants of the interaction between tick serpins and serine proteases.

Serpin name	Tick species	Protease	Second-order rate constant (M-1 s-1)	References
AAS27	A. americanum	trypsin	6.46 ± 1.24 x 104	Tirloni et al., 2019
AAS41	A. americanum	chymase	5.6 ± 0.37 x 103	Kim et al., 2020
		α-chymotrypsin	1.6 ± 0.41 x 104
Iripin-3	I. ricinus	kallikrein	8.46 ± 0.51 x 104	Chlastáková et al., 2021
		matriptase	5.93 ± 0.39 x 104
		trypsin	4.65 ± 0.32 x 104
		thrombin	1.37 ± 0.21 x 103
Iripin-8	I. ricinus	plasmin	2.25 ± 0.14 x 105	Kotál et al., 2021
		trypsin	2.94 ± 0.35 x 104
		kallikrein	1.67 ± 0.11 x 104
		fXIa	1.63 ± 0.09 x 104
		thrombin	1.38 ± 0.1 x 104
		fXIIa	3.32 ± 0.41 x 103
		fXa	2.09 ± 0.12 x 103
		activated protein C	5.23 ± 0.35 x 102
		fVIIa + tissue factor	4.56 ± 0.35 x 102
Iris	I. ricinus	leukocyte elastase	4.7 ± 0.64 x 106	Prevot et al., 2006
		pancreatic elastase	2.2 ± 0.15 x 105
		tissue plasminogen activator	2.9 ± 0.15 x 105
		fXa	1.7 ± 0.36 x 105
		thrombin	2.5 ± 0.42 x 104
		trypsin	1.5 ± 0.42 x 104
RmS-15	R. microplus	thrombin	9.3 ± 0.5 x 104	Xu et al., 2016

All tick serpins with available data are presented.