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. 2022 May 27;13:878297. doi: 10.3389/fmicb.2022.878297

Figure 3.

Figure 3

Network topologies of the significant MCODE clusters. MCODE-derived cluster 1: score 11.2, nodes 21 (mapk14, jun, stat3, mapk8, mapk9, mapk3, myc, ets2, rin1, akt1, atg5, atg7, atg12, atg3, banf1, atg16l1, atg4c, atic, aprt, acaca, and prkaa1), and edges 112 (A). MCODE-derived cluster 2: score 8.894, nodes 48 (gli2, myd88, wdtc1, tlr4, ang, nos2, agtr1, mlkl, fadd, sqstm1, ripk3, becn1, mfn2, bcl2l1, loc728519, alpi, diablo, birc2, xiap, bcl2, bax, mmp2, mmp9, col1a1, col1a2, ogn, prelp, mmp1, mmp3, mmp12, frap1, pik3ca, ifi27, hspg2, soat1, bbc3, tp53, cdkn1a, mdm2, pmaip1, ddit3, runx1, atf4, pp1r15a, slc12a3, rictor, id2, and tsc2), and edges 209 (B). MCODE-derived cluster 3: score 7, nodes 7 (atp5b, pdk4, atp8a2, cycs, acadm, 1.2.2.2, and 3.6.3.14), and edges 21 (C). MCODE-derived cluster 4: score 5, nodes 5 (smad7, pten, dgcr5, mirn21, and mirn23a), and edges 10 (D). MCODE-derived cluster 7: score 4.48, nodes 26 (il1b, il6, tnf, il10, ifng, atn1, nod2, nod1, clec7a, clec4e, stat5a, parp1, mcl1, ervk2, erbb2, erbb3, egfr, hdac1, ephb2, ros1, sod1, ppa1, dynamin, igfals, tardbp, and cmp1), and edges 56 (E). MCODE-derived cluster 8: score 4, nodes 7 (ccr1, ccr5, atgr2, il8, csf2, cxcl1, and ccl5), and edges 12 (F).