Table 2.
Identified probiotic strains and the corresponding training gene sets associated with CRC-triggering gut inflammation.
| References | Probiotic strain | Training genes |
|---|---|---|
| Cruz et al. (2020) | S. thermophilus BT01, B. breve BB02, B. animalis subsp. lactis BL03, B. animalis subsp. lactis BI04, L. acidophilus BA05, L. plantarum BP06, L. paracasei BP07, L. helveticus BD08 |
il-2, il-4, il-6, il-10, il-17, tnf, ifn |
| Roller et al. (2007) | L. rhamnosus GG (LGG), B. lactis Bb12 (BB-12) | il-2/ifn-g, tnf-α/il-12, il-10, pge2, tgf-β1 |
| Kaeid Sharaf and Shukla (2018) | L. acidophilus NCDC #15, L. rhamnosus GG MTCC #1408 | ctnnb1, nf-κb1, cox-2 |
| Mahkonen et al. (2008) | L. acidophilus 74-2, L. rhamnosus GG, B. lactis sp. 420 (Bif420) | cox-1, cox-2 |
| Deol et al. (2018) | L. acidophilus MTCC 5401 | cox-2, inos, c-myc |
| Oh et al. (2018), Dong et al. (2012) | L. rhamnosus 4B15 (4B15), L. acidophilus, B. bifidum MF 20/5, L. gasseri 4M13 (4M13), L. casei Shirota, L. rhamnosus GG, L. plantarum NCIMB 8826, L. reuteri NCIMB 11951, B. longum SP 07/3 | il-6, il-1β, il-10, il-4, il-13, tnf, tgfβ1 |
| Walia et al. (2018) | L. plantarum (AdF10), L. rhamnosus GG (LGG) | gsh, gpx, gst, sod1, cat, tp53, p21, bcl2, bax, casp3, casp9 |
| Sharifi et al. (2017) | L. paracasei, L. kefiri, L. parabuchneri, Acetobacter lovaniensis | tgfβ1, tnf-α, bcl2, bax, p53, p21 |
| Madempudi and Kalle (2017) | B. coagulans Unique IS2 | bcl2, bax, tp53, parp1, cytc, actb, casp-3 |
| Irecta-Nájera et al. (2017) | E. durans, L. casei ATCC 393 | odc1 |
| Huang et al. (2019) | S. thermophilus, L. rhamnosus, L. acidophilus, L. casei, B. bifidum, B. longum, L. casei variety rhamnosus Lcr35, L. acidophilus, B. bifidum LaBi | tnf-α, il-1β, ifnγ, il-6, il-10, il-1, il-17 |
| Daniluk et al. (2012) | L. helveticus, S. thermophilus, L. bulgaricus | bcl2, bax, tlr2, tlr4, nod1, nod2, nlrp6 |
| Karimi Ardestani et al. (2019) | L. paracasei IBRC M10784, L. brevis IBRC M1079 | bcl2, bax, casp-3, casp-9, b-actin |
| Talero et al. (2015) | S. thermophilus DSM24731, L. acidophilus DSM24735, L. delbrueckii spp. bulgaricus DSM24734, L. paracasei DSM24733, L. plantarum DSM24730, B. longum DSM24736, B. infantis DSM24737, B. breve DSM24732 | tnf-α, il-1b, il-6, il-10, cox-2 |
| Chen et al. (2012) | L. acidophilus NCFM (La) | cxcr4, cxcl12, mhci |
| Lan et al. (2007) | Propionibacterium freudenreichii subsp. freudenreichii strain TL142 | casp-8, casp-9, casp-3, casp-7, rip1, parp, cyt c, bax, vdac |
| Femia et al. (2002) | B. lactis (Bb12), L. rhamnosus (LGG) | gst, cox-2, inos |
| Parisa et al. (2020) | B. breve, L. reuteri, L. plantarum, L. rhamnosus, L. brevis, B. bifidum, B. longum | egfr, her-2, ptgs-2, cox-2 |
| Oh et al. (2020) | L. gasseri 505 | sod, cat, gr, gpx, tnf-α, cox-2, mpo, nf-κb |
| Agah et al. (2019) | B. bifidum (Bla/016P/M), L. acidophilus | ifn-γ, il-10 |
| An et al. (2019) | L. rhamnosus KCTC 12202BP | p53, p21, cyclin b1/cdk1 |
| An and Ha (2016) | L. plantarum | cd44, 133, 166, aldh1, casp-3 |
| Baldwin* et al. (2010) | L. acidophilus CL1285, L. casei LBC80R | casp-3, p21 |
| Bassaganya-Riera et al. (2012) | L. casei, L. plantarum, L. bulgaricus, L. acidophilus, B. longum, B. breve, B. infantis, S. thermophilus | tnf-α, angiostatin, ppar c, cox-2, il-17, cd36 |
| Bertkova et al. (2010) | L. plantarum | tnf-α, il-6 |
| Borowicki et al. (2011) | L. rhamnosus GG (LGG), B. lactis Bb12 (Bb12) | p21, dr5, wnt2b |
| Chen et al. (2009) | S. boulardii | erk1/2, mek1/2, her-2, her-3, igf-1r, egfr, erk, mek, camkii kinases, pkc, egfr, igf1r, her-2, her-3, akt |
| Chen et al. (2015) | B. subtilis (ATCC 23857), C. butyricum (ATCC 19398) | tlr4, myd88, p21, il-22, survivin, nf-κb, erk |
| Chen et al. (2017) | L. johnsonii BCRC17010, L. delbrueckii subsp. bulgarius BCRC10696, L. salivarius BCRC14759, L. reuteri BCRC14625, L. brevis PM150, L. plantarum PM153, L. brevis PM177 | bax, bcl-2, ldh, no |
| Chondrou et al. (2018) | L. paracasei K5, L. casei ATCC 393, L. rhamnosus GG ATCC 53103 | bcl-2, bcl-xl, bak, bax, bad, b-actin |
| Chung et al. (2017) | VSL#3: L. acidophilus, L. plantarum, L. casei, L. delbrueckii subsp. bulgaricus, B. breve, B. longum, B. infantis and S. salivarius subsp. thermophilus | anti-pampk, anti-ampk, anti p-perk1/2, anti-perk1/2, anti-pakt, anti-akt, anti-cyclin d1, anti- bcl-2 |
| Chung et al. (2019) | E. faecalis strain KH2, Proteus mirabilis (ATCC 12453) | il-1β, casp-1 |
| Cousin et al. (2016) | Propionibacterium freudenreichii ITG P9 | casp-8, cyt c, hsc70, p21, parp-1, flip, casp-3, casp-9, bax, bak, bcl-xl, mcl-1, xiap, histone h3 |
| Del Carmen et al. (2016) | S. thermophilus CRL807, L. delbrueckii subsp. bulgaricus CRL864 | il-10, il-17, mcp-1, tnf-α |
| Djaldetti and Bessler (2017) | S. thermophilus, L. rhamnosus, L. acidophilus, L. casei, B. bifidum, B. longum | tnf-α, il-1β, il-6, ifnγ, il-10, il-1ra |
| Ewaschuk et al. (2006) | L. casei, L. plantarum, L. acidophilus, L. delbrueckii subsp. bulgaricus, B. infantis, B. breve, B. longum, S. salivarius subsp. thermophilus | pparg |
| Fahmy et al. (2019) | B. longum (BL) | il-1β, il6, mir-21a, mir-155, mir-145, mir-15a, nf-κb |
| Foo et al. (2011) | B. longum BCRC 910051, L. gasseri BCRC 910197 | pcna, p27, cyclin a, cyclin b, cyclin e, cdc-2, cdk-2 |
| Gamallat et al. (2016) | L. rhamnosus GG CGMCC 1.2134 (LGG) | tnf-α, bcatenin, nfkb, p65, casp-3, cox-2, bax, bcl-2, inos, vegfa, p53, b-actin |
| Golkhalkhali et al. (2018) | L. acidophilus BCMCR 12130, L. casei BCMCR 12313, L. lactis BCMCR 12451, B. bifidum BCMCR 02290, B. longum BCMCR 02120, B. infantis BCMCR 02129 | crp, il-6, tnf-α |
| Hadad et al. (2019) | L. rhamnosus | tnf-α, il-6 |
| Heydari et al. (2019) | B. bifidum (Bla/016P/M), L. acidophilus (LA) | mir-135b, mir-26b, mir-18a-3p, mir-155-5p, apc, pten, kras, pu.1, b-actin |
| Ko et al. (2007) | L. plantarum (ATCC 8014) | tnf-α, il-8, erk |
| Konishi et al. (2016) | L. rhamnosus GG ATCC53103, L. casei ATCC334, L. coryniformis ATCC25600, L. fermentis ATCC23271 | ddit3, e p44/ 42 mapk (erk), akt, jnk, p38mapk, gsk3b, casp-3, parp |
| Kuugbee et al. (2016) | L. acidophilus, B. bifidum, B. infantum | muc2, zo-1, tlr2, tlr4, casp-3, cox-2, b-catenin |
| Liu et al. (2013) | L. plantarum CGMCC no.1258, L. acidophilus-11, B. longum-88 | p38 mapk |
| Ma et al. (2010) | B. polyfermenticus | erbb2, erbb3, e2f, h2a, il-8 |
| Mendes et al. (2018) | L. acidophilus, L. rhamnosus, B. bifidum | il-6, il-1β, tnf, il-10, il-4, il-13, tgfβ1 |
| Mi et al. (2017) | B. infantis | tnf-α, il- 1β, il-6, t-bet, il-2, il-10, tgf-β, il-12, ifn-γ, il-23, il-21, il-17, rorγt, foxp3, gapdh |
| Norouzi et al. (2018) | L. lactis subsp. lactis | cea, ceam6, mmp2f |
| Rong et al. (2019) | L. helveticus NS8 | tnf-α, il-8, il-10, nf-κb, |
| Song et al. (2018) | B. longum, L. acidophilus, E. faecalis | cxcl1, cxcl2, cxcl3, cxcl5, tnfa, il1b, il6, ptgs1 |
| Lee et al. (2020) | L. fermentum | bax, bak, noxa, parp1, bcl-xl, p-iκbα |
| Do et al. (2016) | VSL#3: L. acidophilus, L. plantarum, L. casei, L. delbrueckii subsp. bulgaricus, B. breve, B. longum, B. infantis and S. salivarius subsp. thermophilus | tnf-α, il-6, mcp-1, ccl2, il-10, il-11, il-17, il-22, arginase-1 |
| Yue et al. (2020) | L. plantarum YYC-3 | tnf-α, il-6, il-17f, il-22, cyclin-d1, c-myc, icam1, vcam1 |
| Kim et al. (2020) | L. johnsonii, L. reuteri, L. rhamnosus GG | il-10, ifn γ, il-17, il-12, p40, tbet, gata3, rorc, foxp3 |
| Dong et al. (2020) | L. salivarius (LS) Ren | akt, jnk, erk, cyclind1, cox2 |
| Tiptiri-Kourpeti et al. (2016) | L. casei ATCC 393 | trail, cyclin d1, birc5a |
| Walia et al. (2015) | L. plantarum (AdF10), L. rhamnosus GG (LGG) | cox-1, cox-2 |
| Chen et al. (2020) | C. butyricum (ATCC 19398) | hgpr41, hgpr43, hgpr109a, hp21waf1, hgapdh, mgpr41, mgpr43, mgpr109a, mgapdh, cyclin d1, c-myc, |
| Saito et al. (2019) | L. casei strain Shirota and B. breve strain Yakult | il-6, stat-3, cox-2, tnf-α, eil-6, stat3, nf-κb, pge-2, cox-2, tnf-α |