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. 2022 May 25;13:884241. doi: 10.3389/fimmu.2022.884241

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Copyright © 2022 Schmitt, Pircher, Steinert, Meier, Ghoreschi, Vielmuth, Kugelmann and Waschke

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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STED microscopy images of single cell borders from control vs. PV patient skin, and confocal image for overview of control, unaffected PV skin and blister region of PV skin. Co-stained for: (A) Dsg1 or Dsg3 (red) and Dp (green). (B) Dsg1 or Dsg3 (red) and Pg (green). (C) Dsg3 (red) and Dsg1 (Green). Fragmented and depleted Dsg3 staining pink arrows, clustered Dsgs white arrows, Fragmented desmosomespink pointers, split desmosomes white pinters, cytoplasmic Dsg-Dp-units white circles. N (body donors)=5, n (cell borders)=2-6.