FIGURE 2.

The LIGPLOT diagram of protein-peptide interaction between the RBD and SPIKENET. The pink color SPIKENET peptide residues are shown on the top and yellow color amino acid residues of the RBD from SARS-CoV- two are shown at the bottom. The SPIKENET peptide consists of 15 amino acid residues, 14 of which are shown in non-bonded interactions with the RBD of SARS-CoV-2, which proves that SPIKENET has a significant binding affinity with the spike glycoprotein-1. These findings strongly suggest that SPIKENET is a potent competitive inhibitor of S1.