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. 2022 May 30;13:864798. doi: 10.3389/fphar.2022.864798

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Copyright © 2022 Paidas, Sampath, Schindler, Cosio, Ndubizu, Shamaladevi, Kwal, Rodriguez, Ahmad, Kenyon and Jayakumar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered AQP levels were identified in various organs post-MHV-1 inoculation. While increased AQPs 1 and 4 have been identified in various organs, AQP1 levels were decreased in lungs post-MHV-1. Further, treatment of MHV-1 inoculated mice with SPK (5 mg/kg) reversed these changes. A widespread increase in AQPs 5 and 8 was observed in mice post-MHV-1 inoculation, and treatment of MHV-1 inoculated mice with SPK (5 mg/kg) reversed these changes. Scale bar = 25 μm. Quantitation of AQPs 1, 4, 5, and 8 immunofluorescence images. ANOVA, n = 5 (Control), 16 (MHV-1) and 7 (MHV-1 + SPK). *p < 0.05 versus control; ^† p < 0.05 verses MHV-1 infected mice. Error bars represent mean ± SEM.