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. 2022 May 27;9:875560. doi: 10.3389/fcvm.2022.875560

TABLE 2.

Univariate and multivariate cox regression analysis between characteristics and overall survival (OS).

Characteristics Univariate analysis
Multivariate analysis
HR (95%CI) p-value HR (95%CI) p-value
Age stratification, year <0.001 <0.001
<50 Reference Reference
50–59 1.002 (0.934–1.075) 0.957 1.076 (1.003–1.154) 0.041
60–69 1.129 (1.054–1.209) 0.001 1.283 (1.197–1.375) <0.001
70–79 1.489 (1.384–1.602) <0.001 1.887 (1.753–2.032) <0.001
≥ 80 2.300 (2.065–2.562) <0.001 3.252 (2.916–3.627) <0.001
Gender
Male Reference
Female 1.006 (0.959–1.054) 0.818
Metastasis <0.001 <0.001
M0 Reference Reference
M1a 4.068 (3.861–4.286) <0.001 4.234 (4.015–4.464) <0.001
M1b 4.789 (4.477–5.122) <0.001 4.956 (4.626–5.309) <0.001
M1c 5.612 (4.833–6.517) <0.001 5.147 (4.397–6.025) <0.001
Pleural effusion 3.187 (2.740–3.706) <0.001
Malignant ascites 3.664 (3.291–4.080) <0.001 1.686 (1.505–1.890) <0.001
Hypertension 1.096 (1.026–1.172) 0.006
Diabetes 1.085 (0.991–1.188) 0.078
Coronary artery disease 1.248 (1.071–1.455) 0.005
Dyslipidemia 0.414 (0.186–0.921) 0.031 0.418 (0.188–0.932) 0.033
Heart failure 5.513 (4.532–6.705) <0.001 2.572 (2.111–3.135) <0.001
Atrial fibrillation 1.372 (0.970–1.942) 0.074
Cerebrovascular disease 1.303 (1.168–1.454) <0.001
Venous thromboembolism 2.072 (1.640–2.617) <0.001 1.308 (1.034–1.653) 0.025
Pericardial effusion 3.000 (2.152–4.182) <0.001
CVCsa 1.194 (1.130–1.261) <0.001

aPatients have at least one kind of cardiovascular comorbidities.