TABLE 2.
Characteristics | Univariate analysis |
Multivariate analysis |
||
HR (95%CI) | p-value | HR (95%CI) | p-value | |
Age stratification, year | <0.001 | <0.001 | ||
<50 | Reference | Reference | ||
50–59 | 1.002 (0.934–1.075) | 0.957 | 1.076 (1.003–1.154) | 0.041 |
60–69 | 1.129 (1.054–1.209) | 0.001 | 1.283 (1.197–1.375) | <0.001 |
70–79 | 1.489 (1.384–1.602) | <0.001 | 1.887 (1.753–2.032) | <0.001 |
≥ 80 | 2.300 (2.065–2.562) | <0.001 | 3.252 (2.916–3.627) | <0.001 |
Gender | ||||
Male | Reference | |||
Female | 1.006 (0.959–1.054) | 0.818 | ||
Metastasis | <0.001 | <0.001 | ||
M0 | Reference | Reference | ||
M1a | 4.068 (3.861–4.286) | <0.001 | 4.234 (4.015–4.464) | <0.001 |
M1b | 4.789 (4.477–5.122) | <0.001 | 4.956 (4.626–5.309) | <0.001 |
M1c | 5.612 (4.833–6.517) | <0.001 | 5.147 (4.397–6.025) | <0.001 |
Pleural effusion | 3.187 (2.740–3.706) | <0.001 | ||
Malignant ascites | 3.664 (3.291–4.080) | <0.001 | 1.686 (1.505–1.890) | <0.001 |
Hypertension | 1.096 (1.026–1.172) | 0.006 | ||
Diabetes | 1.085 (0.991–1.188) | 0.078 | ||
Coronary artery disease | 1.248 (1.071–1.455) | 0.005 | ||
Dyslipidemia | 0.414 (0.186–0.921) | 0.031 | 0.418 (0.188–0.932) | 0.033 |
Heart failure | 5.513 (4.532–6.705) | <0.001 | 2.572 (2.111–3.135) | <0.001 |
Atrial fibrillation | 1.372 (0.970–1.942) | 0.074 | ||
Cerebrovascular disease | 1.303 (1.168–1.454) | <0.001 | ||
Venous thromboembolism | 2.072 (1.640–2.617) | <0.001 | 1.308 (1.034–1.653) | 0.025 |
Pericardial effusion | 3.000 (2.152–4.182) | <0.001 | ||
CVCsa | 1.194 (1.130–1.261) | <0.001 | – |
aPatients have at least one kind of cardiovascular comorbidities.