Fig. 5.
Whole-brain voxel-wise analysis results. Top: Group comparison of regulation-related activity (far, negative greater than close, negative) in the luteal phase v. the follicular phase, showing significantly greater activation in the right precentral gyrus during the follicular phase in PMDD women, N = 18/group, FWE cluster corrected, Z > 2.3, p < 0.05, centered on peak voxel at 58, −4, 34. Bottom: A similar analysis showed significantly greater regulation-related activity in the right postcentral gyrus of healthy controls compared with women with PMDD, both tested in the luteal phase, FWE cluster-corrected, Z > 2.3, p < 0.05, centered on peak voxel at 42, −28, 58.