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. 2022 Jun 14;28(2):553–563. doi: 10.1038/s41380-022-01632-5

Fig. 4. Network of functional interactions between the differentially expressed plasma biomarkers (plain squares for cytokines or chemokines; dashed squares for growth factors, double circle for complex/group), canonical pathways (CP) and clinical pathology endpoints (Tx).

Fig. 4

(1) LIF protein increases expression of HGF mRNA [91]; (2) IL1RN protein decreases production of CSF protein [92]; (3) CSF protein increases its own dimerization [93]; (4) HGF increases secretion of IL10 protein [94]; (5) HGF protein decreases expression of CCL2 mRNA [95]; (6) IL10 protein increases expression of IL1RN mRNA [96]; (7) IL10 protein increases release of CXCL10 protein [97]; (8) IL10 protein increases expression of human IL10 mRNA [98]; (9) CCL2 mRNA is increased by CCL2 protein [99]; (10) IL31 protein increases expression of CCL2 mRNA [100, 101]).