Table 2.

Significant correlations between performance on the Rey–Osterrieth Complex Figure Test and neuroimaging measurements of gray and white matter volumes (MRI) and glucose metabolism (FDG-PET).

Brain regiona	Direction of significant correlation	Cluster sizeb	Coordinatesc			Peak Z-scored
			x	y	z
Gray matter volume
No significant correlations.	–	–	–	–	–	–
White matter volume
Left and right genu of the corpus callosum, extending to the cingulum bundle	Negative	1426	−6	26	−2	4.32
Right fusiform gyrus	Negative	93	32	−22	−26	4.01
Right lingual gyrus	Negative	127	30	−44	−8	3.84
Right inferior frontal gyrus	Negative	98	40	6	16	3.76
Left lingual gyrus	Negative	41	−18	−52	2	3.73
Left inferior frontal gyrus	Negative	20	−34	30	−2	3.48
Left inferior fronto-occipital fasciculus	Negative	15	−24	4	−8	3.47
Left inferior fronto-occipital fasciculus	Negative	15	−32	−10	−8	3.44
Right inferior fronto-occipital fasciculus	Negative	13	32	−10	−8	3.43
Glucose metabolism (FDG-PET)
Left inferior temporal gyrus	Positive	34	−56	−46	−22	3.96
Left inferior occipital gyrus (superior portion)	Positive	53	−48	−68	−16	3.92
Right dorsal anterior cingulate gyrus	Negative	69	8	16	42	4.61
Right Rolandic operculum and opercular part of the inferior frontal gyrus	Negative	57	52	8	12	4.48
Right inferior occipital gyrus	Negative	62	38	−74	−6	4.15
Left calcarine and lingual gyri	Negative	66	−14	−92	−8	3.88
Left superior frontal gyrus	Negative	50	−16	60	−8	3.75
Left inferior occipital gyrus (inferior portion)	Negative	19	−30	−82	−8	3.46
Right medial frontal and orbital frontal gyri	Negative	20	18	54	−4	3.43

^aFor the analysis of white matter volumes, the brain regions where voxel clusters were located were identified according to the MRI Atlas of Human White Matter (Oishi et al., 2010). For the analysis of glucose metabolism, brain regions were identified according to the Automatic Anatomical Labeling Toolbox for SPM12 (Rolls et al., 2015).

^bNumber of contiguous voxels in each cluster that surpassed the initial cutoff of p <= 0.0005.

^cMNI coordinates of the voxel of maximal statistical significance within each cluster.

^dZ-score for the voxel of maximal statistical significance in each region.