Table 1. Characteristics of patients with malignancy-related dermatoses (paraneoplastic dermatoses).
| Paraneoplastic dermatosis | Sex | Age at disease onset | Duration of skin lesions before seeing a dermatologist | Time from first dermatologic exa-mination to malig-nancy detection | Positive tumor markers | Other useful diagnostic tools | Malignancy | Outcome |
|---|---|---|---|---|---|---|---|---|
| 1 Eczematous dermatitis | M (Fig. 1a, b, c) | 52 years | 4 months | 66 months | CEA, CYFRA | EGD | Gastric cancer | In remission |
| F | 54 years | 2 months | 9 months | Normal | US | Endometrial cancer | In remission | |
| M | 64 years | 3 months | 24 months | PSA | Prostate biopsy | Prostate cancer | In remission | |
| 2 Vasculitis | M (Fig. 1d, e) | 66 years | 1 month | 1 month | AFP | US, CT | Hepatocellular cancer | Died |
| M | 56 years | 1 month | 72 months | CYFRA, AFP | CT, bronchoscopy | Lung cancer | In remission | |
| F | 70 years | 3 months | 6 months | Normal | EGD | Gastric cancer | In remission | |
| 3 Subacute cutaneous lupus erythematosus | M (Fig. 1f, g, h) | 64 years | 3 months | 18 months | CA 19-9, CEA | EGD | Gastric cancer | Died |
| F | 79 years | 1 month | 40 months | Normal | Cystoscopy | Bladder cancer | In remission | |
| 4 Pruritus | F | 54 years | 24 months | 24 months | LDH | CT, lymph node cytopunction, bone marrow biopsy | Lymphoma (HL) | Died |
| M | 75 years | 12 months | 48 months | Normal | Bone marrow aspiration | Multiple myeloma | In remission | |
| 5 Chronic urticaria and angioedema | F | 89 years | 1 month | 2 months | Normal | US, lymph node cytopunction | Lymphoma (non-HL) | Died |
| M | 67 years | 3 months | 36 months | PSA | Prostate biopsy | Prostate cancer | In remission | |
| 6 Alopecia areata | M (Fig. 2a, b) | 49 years | 4 months | 3 months | Normal | Thyroid hormones, antibodies, US | Thyroid cancer | In remission |
| 7 Dermato-myositis | M (Fig. 2c, d) | 62 years | 2 months | 1 month | LDH | EGD | Esophageal cancer | Died |
| F | 32 years | 36 months | 18 months | Normal | Thyroid hormones, antibodies, US | Thyroid cancer | In remission | |
| 8 Flushing | F | 32 years | 36 months | 18 months | Normal | Thyroid hormones, antibodies, US | Thyroid cancer | In remission |
| 9 Bullous pemphigoid | F | 70 years | 1 month | 1 month | Normal | US, CT | Kidney cancer | In remission |
| 10 Localized scleroderma | F | 71 years | 12 months | 6 months | Normal | Cystoscopy | Bladder cancer | In remission |
| Mean age/duration | 63.17 years | 6.65 months | 22.06 months |
M = male; F = female; CEA = carcinoembryonic antigen; LDH = lactate dehydrogenase; CYFRA = cytokeratin fragment; EGD = esophagogastroduodenoscopy; PSA = prostate-specific antigen; AFP = alpha fetoprotein; CA 19-9 = cancer antigen 19-9; LDH = lactate dehydrogenase; US = ultrasonography; CT = computed tomography