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. 2022 May 30;9:860186. doi: 10.3389/fmed.2022.860186

Table 1.

miRNAs in PAS.

miRNAs Trend Sample Gestational weeks Target signaling molecular Function Ref
hsa-miR-10524-5p hsa-miR-133a-3p
hsa-miR-937-3p
hsa-miR-34b-5p
hsa-miR-3529-3p
hsa-miR-488-3p
hsa-miR-490-3p
↑/↓ Peripheral blood plasma Before cesarean section Angiogenesis and blood vessel morphogensis (22)
hsa-miR-17-5p
hsa-miR-21-5p
hsa-miR-25-3p
hsa-miR-92a-3p
hsa-miR-320a-3p
Peripheral blood plasma 30–34w Clusterin Regulate the epithelial- mesenchymal transition, decrease the expression level of clusterin (23)
miR-196a-5p, miR-518a-3p, miR-139-3p
miR-671-3p
Venous blood third trimester NF-κB, ANXA1, MMP11,
E-cadherin
Angiogenesis, embryonic development, cell migration and adhesion, and tumor-related pathways (24)
Micro-7 Peripheral blood plasma TGF-β Promotes trophoblast invasion (25)