Table 1.
miRNAs in PAS.
miRNAs | Trend | Sample | Gestational weeks | Target signaling molecular | Function | Ref |
---|---|---|---|---|---|---|
hsa-miR-10524-5p hsa-miR-133a-3p hsa-miR-937-3p hsa-miR-34b-5p hsa-miR-3529-3p hsa-miR-488-3p hsa-miR-490-3p |
↑/↓ | Peripheral blood plasma | Before cesarean section | – | Angiogenesis and blood vessel morphogensis | (22) |
hsa-miR-17-5p hsa-miR-21-5p hsa-miR-25-3p hsa-miR-92a-3p hsa-miR-320a-3p |
↑ | Peripheral blood plasma | 30–34w | Clusterin | Regulate the epithelial- mesenchymal transition, decrease the expression level of clusterin | (23) |
miR-196a-5p, miR-518a-3p, miR-139-3p miR-671-3p |
↓ | Venous blood | third trimester | NF-κB, ANXA1, MMP11, E-cadherin |
Angiogenesis, embryonic development, cell migration and adhesion, and tumor-related pathways | (24) |
Micro-7 | ↓ | Peripheral blood plasma | – | TGF-β | Promotes trophoblast invasion | (25) |