Table 2.

Biomarkers of aneuploidy in PAS.

Marker	Study	Trimester	Gestational weeks	Total case	Cut-off value	Sensitivity	Specificity	P	Predict the prognosis
AFP	Oztas et al.	second	16–20w	316	1.25MoM	0.8594	0.7143	=0.036	Y
	Berezowsky et al.	second	16–19+6w	301	0.99MoM	0.71	0.46	<0.027	Y
β-hcg	Thompson et al.	first	11–13w	560	0.81MoM	–	–	=0.061	N
	Buke et al.	first	–	88	1.42MoM	–	–	=0.042	N
	Berezowsky et al.	second	16–19+6w	301	1.25MoM	0.53	0.68	<0.0001	Y
PAPP-A	Thompson et al.	first	11–13w	560 (33AIP)	1.40MoM	–	–	=0.002	N
	Lyell et al.	first	10w 0d−13w 6d	736 (37AIP)	2.63MoM	–	–	–	N
	Penzhoyan et al.	first	11w 0d−13w 6d	87 (25AIP)	1.30MoM	–	–	=0.640	Y

N, No; Y, Yes.