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. 2022 May 27;12:873839. doi: 10.3389/fonc.2022.873839

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Copyright © 2022 Du, Zhou, Mao, Shu, Xiao, Ye, Xu, Shen, Lin, Fang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A 62-year-old male patient with glioblastoma of the right fronto-parietal lobe with corpus callosum involvement, WHO grade IV, IDH-wild type. (A–C) MRI axial T2W, T1W, T2-FLAIR sequences showed multiple cystic lesions within the tumor, with uneven signals and severe peritumor edema. (D) T1 postcontrast showed obvious irregular and thick rim enhancement. (E, F) When b value is 1000, tumor was locally obvious restricted diffusion in DWI and ADC images. (G) HE staining showed increased cell density and marked atypia, accompanied by extensive necrosis (×200). (H) IDH1 negative expression (×200).