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. 2022 May 30;13:887238. doi: 10.3389/fendo.2022.887238

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Copyright © 2022 Wang, Jiang, Lu, Feng, Ma, Zhang, Guan, Yang, Fan, Zhu, Yang, Qi, Yang, Li, Zhao, Jiang, Tian and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pro³-GIP blocked the analgesic and anxiolytic effects of D-Ala²-GIP. Administration of Pro³-GIP prevented the D-Ala²-GIP-induced increases of paw withdrawal threshold and latency in CFA-injected mice (A–D). Pro³-GIP also inhibited the anxiolytic effects of D-Ala²-GIP in OF test (E–H) and EPM test (I–L). n = 8 in each group except for the groups of (C, D) (n = 6). Totally, 56 mice were used in this section. D-Ala² means D-Ala²-GIP; Pro³ means Pro³-GIP. ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001, ^**** p < 0.0001.