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. 2022 Jun 8;11(1):2085432. doi: 10.1080/2162402X.2022.2085432

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Expression of FABP5 in the TAME is tightly linked to the polarization of CD163⁺macrophage and predicts survival in breast cancer.

(a) Comparison of FABP5 mRNA expression in normal and tumor breast tissues in the TCGA datasets. (b) FABP5 mRNA expression in different breast cancer subtypes in the breast cancer cohort of TCGA. (c) Correlation analyses between the protein expression levels of FABP5 and CD163 in the TCGA datasets. (d) Kaplan-Meier plots of human BRCA specimens from the TCGA datasets (1082 patients) based on low vs. high gene expression of FABP5. (e) Representative immunohistochemical images of FABP5 in tumor invasive margins and tumor tissues, respectively. (f, i) Kaplan-Meier survival analysis of patients with FABP5-positive and -negative IHC staining in the margin or tumor tissues, respectively. (g, j) Correlation analyses between the protein expression levels of FABP5 and CD163 in the margin or tumor tissues, respectively. (h) Kaplan-Meier survival analysis of patients with biomarker-positive and -negative IHC staining in the margin.*, p < .05; **, p < .01; ***, p < .001; ****, p < .0001; ns, not significant; Correlation calculations represent Pearson’s coefficient.