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. 2022 Jun 8;11(1):2085432. doi: 10.1080/2162402X.2022.2085432

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Lipid-associated macrophages promote breast cancer progression.

(a) Workflow of the bioinformatic analysis. (b) Reclustering of macrophages, UMAP visualization and marker-based annotation of 10 macrophage subtypes, colored by cluster identity. (c) Heatmap of DEGs between different macrophage subgroups. Selected genes of interest from each signature are listed. (d) Box plots show the enrichment scores of the M1 signature and M2 signature in the non-LAM and LAM, respectively. (e) Box plots show the enrichment scores of the angiogenesis signature and phagocytosis signature in the non-LAM and LAM, respectively. (f) The distributions of ADIPOQ and LAM signature in the BRCA ST datasets, respectively. (g) Box plots show the enrichment scores of the LAM signature and LYZ signature in the ADOPOQ- and ADOPOQ+ group, respectively. (h) Kaplan-Meier plots showing differences in survival among BRCA patients stratified based on the top and bottom 30% selected LAM signature scores. P values from log-rank test statistics.